immunofluorescence reagents
  • Can vitamin D ward off respiratory tract infections?
    Can vitamin D ward off respiratory tract infections? January 11, 2022
    Vitamin D For Prevention of Respiratory Tract Infections (COVID-19) What is Vitamin D? Vitamin D is a fat-soluble-vitamin, unlike most other vitamins which are generally obtained through dietary sources, in that a major source derives from UV light-induced conversion of its precursor under the skin which means Vitamin D can be produced by the body itself through exposure to sunlight. Vitamin D is not naturally present in most foods. Dietary sources include fortified foods and supplements. Fatty fish and fish liver oils are among the few quality sources of vitamin D, and smaller amounts are found in beef liver and some mushrooms. (WHO, n.d.) (Lukaszuk and Luebbers, 2017) Studies have shown that there is a high prevalence of vitamin D deficiency worldwide. (WHO, n.d.) Why is Vitamin D Important? Vitamin D deficiency may affect the immune system as vitamin D plays an immunomodulation role, enhancing innate immunity by up-regulating the expression and secretion of antimicrobial peptides, which boosts mucosal defences. Furthermore, recent meta-analyses have reported a protective effect of vitamin D supplementation on respiratory tract infections. (WHO, n.d.) Traditionally, vitamin D deficiency has been associated with rickets, a disease in which the bone tissue doesn't properly mineralize, leading to soft bones and skeletal deformities. But increasingly, research is revealing the importance of vitamin D in protecting against a host of health problems including: l  Increased risk of death from cardiovascular disease l  Cognitive impairment in older adults l  Severe asthma in children l  Cancer (Davis, 2009) Vitamin D Supplementation to Prevent Acute Respiratory Tract Infections Respiratory tract infections are conditions that affect the air passages. These include acute infections that affect the lower respiratory tract and lungs, such as pneumonia and influenza, which are among the leading causes of death in children worldwide. (WHO, n.d.) In 2015, 16% of all deaths in children under five years of age were attributed to pneumonia. Pneumonia is usually caused by a bacterial infection and can also be caused by a virus, such as coronavirus (COVID-19). These conditions may also have an impact on quality of life. Therefore, it is important to find interventions that could prevent respiratory conditions. (WHO, n.d.) A constant effort has been put into addressing those diseases caused by Vitamin D deficiency. And so far to our knowledge, observational studies report consistent independent associations between low serum concentrations of 25-hydroxyvitamin D and susceptibility to acute respiratory tract infection. In a recent-year research conducted by a whole lot of health professionals to find out the role of Vitamin D in preventing respiratory infections, they came to a conclusion: “Vitamin D supplementation reduced the risk of acute respiratory tract infection among all participants. And protective effects were seen in those receiv...
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  • Cardiac Blood Test - A Quick Walkthrough
    Cardiac Blood Test - A Quick Walkthrough October 21, 2021
    Your blood offers many clues about your heart health. Aside from cholesterol level in your blood which can be a sign of whether you have a heart attack, other substances in your blood can also tell you about your heart health. It's important to remember that one blood test alone doesn't determine your risk of heart disease. It often takes several different blood tests for doctors to diagnose and manage heart disease. In this article, we will focus on some of them and take a quick look at why you may need this test. Cardiac biomarkers are substances that are released into the blood when the heart is damaged or stressed. Measurements of these biomarkers are used to help diagnose acute coronary syndrome (ACS) and cardiac ischemia, conditions associated with insufficient blood flow to the heart. Tests for cardiac biomarkers can also be used to help determine a person’s risk of having these conditions or to help monitor and manage someone with suspected ACS and cardiac ischemia. Troponin Troponin is a protein released into your bloodstream when your heart muscle is being damaged. This protein is by far the most commonly used biomarker. It has the highest known sensitivity. An increased level of troponin protein in your blood has been linked with the amount of heart damage following a heart attack and a higher risk of heart disease in people who have no symptoms so it is often done if you have chest pain. (UNIVERSITY OF ROCHESTER MEDICAL CENTER, 2021) Myoglobin Myoglobin is a small protein that stores oxygen. It is measured occasionally. Myoglobin is sometimes measured in addition to troponin to help diagnose a heart attack. It is also not very specific for finding a heart attack. (UNIVERSITY OF ROCHESTER MEDICAL CENTER, 2021) B-type natriuretic peptide (BNP) B-type natriuretic peptide (BNP) is a protein that your heart and blood vessels make. BNP helps your body eliminate fluids, relaxes blood vessels and moves sodium into your urine. For people who have heart failure, establishing a baseline BNP can be helpful and future tests can be used to help measure how well treatment works. BNP has a variation called N-terminal BNP which is also useful for diagnosing heart failure and for assessing the risk of a heart attack and other problems in those with existing heart disease. (Mayo Clinic, 2021) CK-MB CK-MB is a subtype of CK. It is more sensitive for finding heart damage from a heart attack. CK-MB rises 4 to 6 hours after a heart attack. But it is generally back to normal in a day or two. Because of this, it's not helpful when a healthcare provider is trying to figure out if your recent chest pain was a heart attack. (UNIVERSITY OF ROCHESTER MEDICAL CENTER, 2021) D-Dimer D-Dimer is one of the protein fragments produced when a blood clot gets dissolved in the body. It is normally undetectable or detectable at a very low level unless the body is forming and breaking down blood clots. Then, its level in the blood can significantly rise. The strength of the D...
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  • National Day Holiday Announcement
    National Day Holiday Announcement September 30, 2021
    This is an official announcement for the National Day of the People Republic of China.   All our clients are informed that we will close on Friday 1st October and will resume business as usual on Wednesday 8th October on account of the National Day holiday. We pay homage to the founding of our nation and the valiant soldiers who laid down their lives for this country.   National Day holiday: 1st October-7th October 2021 Reopening date: 8th October 2021 During the time, if you have questions regarding the business, please feel free to call the office.   Congratulations and Thank You Everyone for Contributing to The Success of Our Enterprise.   Xiamen Biotime Biotechnology Co., Ltd 30th September, 2021
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  • Chemiluminescent Immunoassay
    Chemiluminescent Immunoassay September 02, 2021
    What is Chemiluminescent Immunoassay Chemiluminescent immunoassay (CLIA) is an immunoassay technique where the label, i.e. the true “indicator” of the analytic reaction, is a luminescent molecule. In general, luminescence is the emission of visible or near-visible radiation which is generated when an electron transition from an excited state to a ground state. The resultant potential energy in the atom gets released in the form of light. (Cinquanta, Fontana and Bizzaro, 2017) Chemiluminescent immunoassays offer one of the best solutions for the quantification of low concentrations of specific analytes from a complex mixture for in vitro diagnostic industry. They can also be used as diagnostic tools in medicine, as well as being used in several other different industries for various applications. (Lorne Laboratories, 2021) How Does Chemiluminescence Work Chemiluminescence immunoassay (CLIA) is an assay that combines the chemiluminescence techniques with immunochemical reactions. The assay format is similar to enzyme-linked immunoassays, usually based on heterogeneous assays where antibodies or antigens are immobilized on a solid phase but one of the components is conjugated with a chemiluminescent label. (Lorne Laboratories, 2021) (BrightTALK, 2021) CLIA utilizes chemical probes which could generate light emission through a chemical reactions to label the antibody. (Creative-diagnostics, 2021) The Benefits of Chemiluminescence Immunoassay In recent years, CLIA has gained increasing attention in different fields, including life science, clinical diagnosis, environmental monitoring, food safety, and pharmaceutical analysis because there are benefits of using chemiluminescence such as: ultra-sensitive good specificity wide range of applications simple equipment wide linear range easier in operation and design can detect small amounts of the biological molecule does not require long incubations and the addition of stopping reagents (Creative-diagnostics, 2021) Key Types of Chemiluminescent Immunoassay Methods Chemiluminescent methods that have been commonly seen are direct - using luminophore markers, indirect—using enzyme markers, or electrogenerated – typically nanomaterials based. (Cinquanta, Fontana and Bizzaro, 2017) (Ju, Lai and Yan, 2017) Indirect CLIA, using enzyme markers This common CLIA method involves an enzyme, typically horseradish peroxidase (HRP) or alkaline phosphatase (AP), conjugated to a secondary antibody. This HRP– or AP–secondary antibody complex then catalyzes the conversion of chemiluminescent substrate, luminol and CSPD reagent respectively. These substrates, when oxidized, provide an easy means of signal detection and quantification due to prolonged signal emission. (Shimadzu, 2021) Direct CLIA, using luminophore markers This method commonly uses acridinium esters as luminophores conjugated directly to the primary monoclonal antibody to generate a signal. Acridinium esters are highly specific labels that spontaneously oxidiz...
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  • Biotime HPLC analyzer// Gold standard for HbA1c measurement
  • [Biotime announcement] - Biotime infection marker interleukin 6 (IL-6) is officially launched!
    [Biotime announcement] - Biotime infection marker interleukin 6 (IL-6) is officially launched! April 22, 2021
    Interleukin is a type of cytokine produced by and acting on a variety of cells. Interleukin 6 (Interleukin 6, abbreviated IL-6) is an important member of the cytokine network, and it has been widely used in many clinical fields. PCT has been widely recognized clinically in differential diagnosis of bacterial infection, risk stratification of sepsis and guidance of antibiotic use. IL-6 is an important cytokine expressed in the initial response of the innate immune system to injury and infection, and plays an important role in the early diagnosis of acute infection. IL-6 combined with PCT has complementary advantages, improves detection sensitivity and specificity, and better facilitates the management of the whole course of sepsis. IL-6 is also one of the important monitoring indicators during the diagnosis and treatment of COVID-19. IL-6 is used for early warning of sepsis After the occurrence of inflammation, IL-6 is the first inflammatory marker. IL-6 will be involved in the occurrence and development of many diseases, and its blood level is closely related to inflammation, viral infection and autoimmune diseases, and its changes are earlier than CRP and PCT. Studies have shown that IL-6 increases rapidly after bacterial infection, PCT increases after 2h, and CRP increases rapidly after 6h [1]. So IL-6 can be used for early warning of sepsis. (Kinetic changes of inflammatory markers in vivo after endotoxin stimulation) IL-6 is used to evaluate the prognosis of sepsis Studies have shown that the high IL-6 concentration during the treatment of sepsis indicates the poor prognosis of patients and the higher mortality rate at the later stage of treatment. The expert consensus on the interpretation of the clinical significance of infection-related biomarkers mentioned that IL-6> at 1000 pg/mL suggests a poor prognosis. Therefore, the detection of IL-6 is also of great significance for the prognosis assessment of sepsis. Application of IL-6 in COVID-19 IL-6 is an important pathway that induces cytokine storm. Cytokine storm is a kind of transitional immune response, and the uncontrolled release of inflammatory factors eventually leads to organ damage and even functional failure. From a large number of research data, it is generally believed that cytokine storm is a key factor in the deterioration of COVID-19 patients. Therefore, IL-6 is also an important monitoring indicator in the diagnosis and treatment of COVID-19, which can be used for early warning of severe/critical COVID-19 and can also help guide the clinical selection of appropriate treatment strategies. a) Key laboratory indicators for COVID-19 patient assessment b) IL-6 levels in 99 confirmed COVID-19 patients Figure (a) In a retrospective multicentric study of 150 confirmed COVID-19 cases, IL-6 in the deceased patients was significantly higher than that in other cases [2]. Figure (b) In a study of 99 patients published in the January 29 Lancet, IL-6 was significantly elevated in more th...
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  • Biotime attended medical trade fair CACLP 2021
    Biotime attended medical trade fair CACLP 2021 March 31, 2021
    Established in 1991, CACLP Expo now is the largest, the most influential and professional trade show in China In Vitro Diagnostics (IVD) and clinical laboratory industry. Biotime, a leading manufacturer of POCT, attended China Association of Clinical Laboratory Practice (CACLP) Expo 2021 from March 28th to 30th at Chongqing International Expo Center. During this CACLP, Biotime exhibited a full line of Point of Care Testing (POCT) reagents and released 3 automated analyzers, named HLC-100 Fully Automated HbA1c Analyzer, FLI-600 FIA Analyzer and FLI-4000 Fully Automated FIA Analyzer. At the same time, Biotime brought a wonderful academic satellite symposium. Cardiology expert Wang Bin was invited to introduce the chest pain center and related cardiac markers. Biotime’s new innovations attracted lots of medical experts and distributors' attention to stop by and communicate with each other. We are so grateful for visitors' support and wish to meet you next year!
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  • Product Recommendations | NGAL- Early Marker of Acute Kidney Injury
    Product Recommendations | NGAL- Early Marker of Acute Kidney Injury July 05, 2021
    What is NGAL? The full name of NGAL is human lipocalin 2 (Ln2) or siderocalin. It belongs to the lipocalin family and is the earliest proposed marker of acute kidney injury (AKI).   What is the clinical significance of NGAL? 1. NGAL is a marker of acute kidney injury (AKI) When AKI occurs, NGAL rises rapidly in a very short period of time, and the most obvious is 2h. Serum creatinine (sCr), urinary enzymes, etc. often increase significantly after 24 to 72 hours. At this time, the glomerular filtration rate (GFR) has decreased significantly, and NGAL can change before GFR decreases, so it is suitable for early diagnosis of AKI. At the same time, the increase in NGAL concentration is closely related to the duration of AKI, the severity of kidney injury (RIFLE classification), and the treatment effect and prognosis. 2、Can predict the progression of chronic kidney disease (CKD), especially diabetic nephropathy Studies have found that NGAL may be involved in the occurrence and development of diabetes as an inflammatory factor. In diabetic nephropathy, renal tubule damage may be earlier than glomerulus. As a marker of early renal tubular damage, NGAL can reflect renal function damage in diabetic patients (especially type 2 diabetes) before urinary microalbumin (mALB). 3、NGAL also has a certain relationship with tumors Data from different laboratories indicate that the concentration level of NGAL is related to a variety of tumors. It promotes cell proliferation by uptake of iron ions and helps tumor cell growth and infiltration. It is related to tumor cachexia and has become an independent predictor of poor prognosis for patients with cachexia. Compared with traditional projects, what are the advantages of NGAL? When AKI occurs, NGAL rises rapidly in a very short time. The following figure shows the time of increase in the concentration of various markers after the occurrence of AKI: Therefore, testing NGAL can buy more time for AKI patients and grasp the best time for treatment. What are the clinical applications of NGAL? Due to the excellent predictive and diagnostic value of NGAL in AKI, the detection of NGAL can be increased in clinical situations that easily cause AKI. · Routine monitoring after major surgery · Monitoring of ICU patients · Triage of conditions in the emergency department · Early diagnosis of AKI caused by infection and sepsis · Contrast nephropathy (CIN) monitoring after interventional therapy...... NGAL is also an evaluation index of chronic kidney disease, so it can also be used to predict the progression of chronic kidney disease and early detection of kidney damage in patients with diabetic nephropathy. The neutrophil gelatinase-associated lipocalin assay kit provided by Biotime uses fluorescence immunochromatography, which is easy to operate and results in 10 minutes. Product Name:NGAL Rapid Quantitative Test Link:
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