Ferritin Quantitative Test

E2 Rapid Quantitative Test (Chemiluminescence Immunoassay)

E2 Rapid Quantitative Test (Chemiluminescence Immunoassay) is used for in vitro quantitative detection of the Estradiol (E2) concentration in human serum and plasma that contains heparin /EDTA and other anticoagulants and samples, mainly used for auxiliary diagnosis of reproductive hormones diseases.

Product Detail

Application

Estradiol (E2), a potent estrogen, controls various biological processes by functioning as a ligand for the nuclear receptors estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ). These estrogen receptors (ERs) can participate in both the genomic (transcriptional) and non-genomic actions of E2.

 

The genomic action of E2 involves the binding of ERα to the regulatory regions of target genes, either directly or through protein-protein interactions. Once DNA-bound, ERα recruits various co-regulatory molecules to induce chromatin modifications that can either increase or decrease the level of target gene transcription.

Several extracellular signal-activated kinases can also phosphorylate and modulate the activity of ERα. This phosphorylation-mediated modulation of ERα activity may be responsible for altered E2 responses, such as resistance to anti-estrogen therapy in breast cancer.

 

The major kinases that have been found to modulate ERα activity include:

1. ERK1/2 (Extracellular signal-regulated Kinases 1 and 2)

2. AKT (also known as Protein Kinase B)

3. RSK (Ribosomal S6 Kinase)

4. PAK1 (p21-Activated Kinase 1)

5. p38 kinase

6. SRC (Proto-Oncogene Tyrosine-Protein Kinase Src)

 

The complex interplay between the genomic and non-genomic actions of E2, mediated through the estrogen receptors and various signaling kinases, highlights the multifaceted mechanisms by which estradiol controls diverse physiological processes.

 

Product Specification

Sample Volume

WB: 50μL; Serum/Plasma: 50μL

Test Time

20 mins

Measuring Range

20-5000 pg/mL

Pack

20T40T100T

Storage

2~30

 

Features

Smart - Photosensitive and Luminescent Microspheres

Rapid - Whole Blood Sample Type Supported & No Centrifuge Needed

Convenient - Room Temperature Storage & Minimal sample consumption

 

Clinical significance

Monitoring Ovarian Function and Menstrual Cycle

Assessment of Ovulation

Evaluation of Menopausal Status

Monitoring Hormone Replacement Therapy (HRT)

Evaluation of Gynecological Disorders

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