IL-6 Rapid Quantitative Test (Chemiluminescence Immunoassay)

Application

Interleukin-6 (IL-6) is a pleiotropic cytokine involved in the physiology of virtually every organ system. Recent studies have demonstrated that IL-6 plays a crucial role in regulating the balance between IL-17-producing T helper 17 (Th17) cells and regulatory T (Treg) cells.

These two T-cell subsets play prominent and opposing roles in immune functions. Th17 cells are key players in the pathogenesis of autoimmune diseases and provide protection against certain bacterial infections, while Treg cells function to restrain excessive effector T-cell responses.

IL-6 induces the development of Th17 cells from naïve T cells, in conjunction with transforming growth factor-beta (TGF-β). In contrast, IL-6 inhibits the TGF-β-induced differentiation of Treg cells. This modulation of the Th17/Treg balance by IL-6 is an important mechanism underlying its involvement in both autoimmunity and host defense.

Product Specification

Features

Smart - Photosensitive and Luminescent Microspheres

Rapid - Whole Blood Sample Type Supported & No Centrifuge Needed

Convenient - Room Temperature Storage & Minimal sample consumption

Clinical significance

Rheumatoid Arthritis and Autoimmune Diseases

Cytokine Release Syndrome (CRS) Assessment

Sepsis and Inflammatory Response

Assessment of Inflammatory Bowel Disease (IBD)

Cardiovascular Risk Assessment