IL-6 Rapid Quantitative Test

Product Introduction

Interleukin 6 (IL-6) is a polypeptide that is consist of two glycoprotein chains; one is the α chain; the other is the β chain. IL-6 is mainly produced by macrophages, monocytes, fibroblasts, lymphocytes and T cells. IL-6 is a prototypical cytokine for maintaining homeostasis. When homeostasis is disrupted by infections or tissue injuries, IL-6 is produced immediately and contributes to host defense against such emergent stress through activation of acute-phase and immune responses. The plasma cytokine interleukin-6 (IL-6) plays an important role in mediating inflammation and is a central stimulus for the acute-phase response. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Therefore, IL-6 is a useful pro-inflammatory cytokine marker [1-7]

Production Specification

Advantages

● Rapid : Results in 15 mins

● Easy & Convenient : Easy operation and no need for extra equipment

● Room temperature to store

Clinical significance

❖ The Biotime IL-6 Rapid Quantitative Test is intended to quantify the concentration of IL-6 (Interleukin-6) in human serum on Biotime FIA Analyzer by fluorescent immunoassay.

❖ The test is used as an aid detection of inflammation.

Application

ICU, Respiratory Medicine, Emergency Department, Cardiology, Laboratory, emergency care

Reference

1. Oberhoffer M,Stonans I,Russwurm S,et al.Procalcitonin expression in Human PeriPheral blood mononuclear cells and its mudalution by lipopolysaccharides and sepsis related cytokines in vitro[J].J Lab Clin Med,1999,134(1):49-55.

2. Hergert M,Kestln HG,Scherkus,et al.Procalcitonin in patients with the ACCP/SCCM consensus definitions than other specific markers of the inflammatory polytrauma[J].Clin Lab,1998,44:659.

3. Naugler W.E., Sakurai T., Kim S., et al. Gender disparity in liver cancer due to sex differences in My D88-dependent IL-6 production[J]. Science. 2007, 317(5834): 121-124.

4. Yuan H., Liddle F.J., Mahajan S., et al. IL-6-induced survival of colorectal carcinoma cells is inhibited by butyrate through down-regulation of the IL-6 receptor[J]. Carcinogenesis. 2004, 25(11): 2247-2255.

5. Cheon Y.K., Cho Y.D., Moon J.H, et al. Diagnostic utility of interleukin-6 (IL-6) for primary bile duct cancer and changes in serum IL-6 levels following photodynamic therapy[J]. American Journal of Gastroenterology. 2007, 102(10): 2164-2170.

6. Hansen JH,et al.HAMA Interference with Murine Monoclonal Antibody-Based Immunoassays[J]J. of Clin Immunoassay,1993,16:294-299.

7. Levinson SS.The Nature of Heterophilic Antibodies and the Role in Immunoassay Interference[J].J of Clin Immunoassay,1992,15:108-114.